The Livestock Metabolome Database (LMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in different livestock species. It is intended to be used for applications in metabolomics, clinical chemistry, biomarker discovery and general education. The database is designed to contain or link three kinds of data: 1) chemical data, 2) clinical data, and 3) molecular biology/biochemistry data. The database contains 1,202 metabolite entries including both water-soluble and lipid soluble metabolites as well as metabolites that would be regarded as either abundant (> 1 uM) or relatively rare (< 1 nM). Each MetaboCard entry contains more than 100 data fields with information being devoted to chemical/clinical data and biochemical data. Many data fields are hyperlinked to other databases (KEGG, PubChem, MetaCyc, ChEBI, PDB, UniProt, and GenBank) and a variety of structure and pathway viewing applets. The LMDB database supports extensive text, sequence, chemical structure and relational query searches. Four additional databases, DrugBank, T3DB, SMPDB and FooDB are also part of the LMDB suite of databases. DrugBank contains equivalent information on ~1600 drug and drug metabolites, T3DB contains information on ~3600 common toxins and environmental pollutants, SMPDB contains pathway diagrams for ~700 human metabolic and disease pathways, while FooDB contains equivalent information on ~28,000 food components and food additives.