Livestock Metabolome Database: Showing metabocard for Serotonin (LMDB00120)

Identification Taxonomy Ontology Physical properties Spectra Biological properties Concentrations Links References XML

Record Information

Version

1.0

Creation Date

2016-07-13 19:42:48 UTC

Update Date

2021-04-30 20:57:45 UTC

Lmdb

LMDB00120

Secondary Accession Numbers

None

Metabolite Identification

Common Name

Serotonin

Description

Serotonin is a biochemical messenger and regulator, synthesized from the essential amino acid L-Tryptophan. Serotonin in the nervous system acts as a local transmitter at synapses, and as a paracrine or hormonal modulator of circuits upon diffusion, allowing a wide variety of "state-dependent" behavioral responses to different stimuli. Serotonin is widely distributed in the nervous system of vertebrates and invertebrates and some of its behavioral effects have been preserved along evolution. Such is the case of aggressive behavior and rhythmic motor patterns , including those responsible for feeding. In vertebrates, which display a wider and much more sophisticated behavioral repertoire, serotonin also modulates sleep, the arousal state , sexual behavior, and others, and deficiencies of the serotonergic system causes disorders such as depression, obsessive-compulsive disorder, phobias, posttraumatic stress disorder, epilepsy, and generalized anxiety disorder. Serotonin has three different modes of action in the nervous system: as transmitter, acting locally at synaptic boutons; upon diffusion at a distance from its release sites, producing paracrine (also called volume) effects, and by circulating in the blood stream, producing hormonal effects. The three modes can affect a single neuronal circuit. (PMID: 16047543 ).

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
3-(2-Aminoethyl)-1H-indol-5-ol	ChEBI
5-HT	ChEBI
5-Hydroxytryptamine	ChEBI
Enteramine	ChEBI
Serotonine	ChEBI
Thrombocytin	ChEBI
Thrombotonin	ChEBI
Hippophaine	HMDB
Hydroxytryptamine	HMDB
5 Hydroxytryptamine	HMDB
3-(2-Aminoethyl)indol-5-ol	HMDB
3-(b-Aminoethyl)-5-hydroxyindole	HMDB
5-HTA	HMDB
5-Hydroxy-3-(b-aminoethyl)indole	HMDB
5-Hydroxy-tryptamine	HMDB
5-Hydroxyltryptamine	HMDB
5-Hydroxytriptamine	HMDB
Antemovis	HMDB
DS Substance	HMDB
Enteramin	HMDB

Chemical Formula

C₁₀H₁₂N₂O

Average Molecular Weight

176.2151

Monoisotopic Molecular Weight

176.094963016

IUPAC Name

3-(2-aminoethyl)-1H-indol-5-ol

Traditional Name

serotonin

CAS Registry Number

50-67-9

SMILES

NCCC1=CNC2=CC=C(O)C=C12

InChI Identifier

InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2

InChI Key

QZAYGJVTTNCVMB-UHFFFAOYSA-N

Chemical Taxonomy

Description

belongs to the class of organic compounds known as serotonins. Serotonins are compounds containing a serotonin moiety, which consists of an indole that bears an aminoethyl a position 2 and a hydroxyl group at position 5.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Indoles and derivatives

Sub Class

Tryptamines and derivatives

Direct Parent

Serotonins

Alternative Parents

Substituents

Serotonin
3-alkylindole
Hydroxyindole
Indole
2-arylethylamine
1-hydroxy-2-unsubstituted benzenoid
Aralkylamine
Substituted pyrrole
Benzenoid
Pyrrole
Heteroaromatic compound
Azacycle
Hydrocarbon derivative
Organopnictogen compound
Amine
Organic oxygen compound
Primary amine
Organooxygen compound
Organonitrogen compound
Primary aliphatic amine
Organic nitrogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

phenols (CHEBI:28790 )
monoamine molecular messenger (CHEBI:28790 )
primary amino compound (CHEBI:28790 )
tryptamines (CHEBI:28790 )
Biogenic amines (C00780 )
Indole alkaloids (C00780 )

Ontology

Status

Detected and Quantified

Origin

Not Available

Biofunction

Not Available

Application

Not Available

Cellular locations

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	0.56	ALOGPS
logP	0.48	ChemAxon
logS	-1.9	ALOGPS
pKa (Strongest Acidic)	9.31	ChemAxon
pKa (Strongest Basic)	10	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	62.04 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	52.35 m³·mol⁻¹	ChemAxon
Polarizability	19.31 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	View
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (5 TMS)	splash10-00di-1900000000-461c2a1f67418e6b5d6a	Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (5 TMS)	splash10-00di-1900000000-2286e87324e9f4a78cb4	Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (Non-derivatized)	splash10-00di-1900000000-927b865023cbba872101	Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (Non-derivatized)	splash10-00di-1910000000-02c17b4cd3336a8bf9b1	Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (5 TMS)	splash10-00di-8900000000-4b838943ace80c8b7734	Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (5 TMS)	splash10-00di-6900000000-a7dd5c569cf4d085d244	Spectrum
GC-MS	GC-MS Spectrum - GC-MS (4 TMS)	splash10-00di-0900000000-2346e553f96cb980c8fc	Spectrum
GC-MS	GC-MS Spectrum - GC-MS (3 TMS)	splash10-00di-1900000000-01fbd5196188d4e0f21c	Spectrum
GC-MS	GC-MS Spectrum - EI-B (Non-derivatized)	splash10-0002-9800000000-9ce9fb2286c3b7ea7719	Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-00di-1900000000-461c2a1f67418e6b5d6a	Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-00di-1900000000-2286e87324e9f4a78cb4	Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-00di-1900000000-927b865023cbba872101	Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-00di-1910000000-02c17b4cd3336a8bf9b1	Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-00di-8900000000-4b838943ace80c8b7734	Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-00di-6900000000-a7dd5c569cf4d085d244	Spectrum
GC-MS	GC-MS Spectrum - GC-MS (Non-derivatized)	splash10-00di-0900000000-2346e553f96cb980c8fc	Spectrum
GC-MS	GC-MS Spectrum - GC-MS (Non-derivatized)	splash10-00di-1900000000-01fbd5196188d4e0f21c	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-001j-6900000000-95a89ff8a3b12e7e8e25	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (1 TMS) - 70eV, Positive	splash10-001i-9450000000-52e0b628b7795c643362	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_2) - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_3) - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_1) - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_2) - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_3) - 70eV, Positive	Not Available	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Linear Ion Trap , negative	splash10-03di-1900000000-d64210214a1b3766ff6e	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 20V, Negative	splash10-004i-1900000000-66be80bf04de85d374b7	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-004i-0900000000-662e21ddee556bb4a222	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 35V, Negative	splash10-004i-0900000000-337ec7823cec887c8ad3	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-004i-0900000000-8ac1f8742228b0c2ada5	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 20V, Negative	splash10-00os-4900000000-fe28a76e9223ea9c3912	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 40V, Negative	splash10-00kf-9200000000-faf92490b8049363f990	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - 40V, Negative	splash10-0006-9500000000-c65e4440ede6c6f45d71	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0a4i-0900000000-6acaf73bcd452e24b886	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-0aor-0900000000-259227b20b82e6362059	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-02e9-5900000000-2f58fbed270523182158	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - EI-B (HITACHI M-80) , Positive	splash10-0002-9800000000-abcd0769bb17d07b3e38	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-03di-0900000000-bf65d809200ea387ebf5	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-03di-0900000000-8a171ac4fdc0474f7f48	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive	splash10-03xr-0900000000-a0b7d8a671909c6f4ad1	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive	splash10-014i-1900000000-fa80d05236eabbafd678	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive	splash10-014i-4900000000-4e2e322d56fc9ee00edd	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-004i-0900000000-c79f0b03a8dc1da0a10a	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Positive	splash10-03fr-0900000000-9cb056cd56bae76589d0	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , positive	splash10-03di-0900000000-08840bc938c367dacbb2	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , positive	splash10-03yi-0900000000-858936972fd87c0c0b14	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , positive	splash10-0159-4900000000-a8fc7dff385a4f51b88a	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF , positive	splash10-00p0-9400000000-7e4063d2b516ae59df84	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-03di-0900000000-bf65d809200ea387ebf5	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-03di-0900000000-8a171ac4fdc0474f7f48	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
2D NMR	[1H,13C] 2D NMR Spectrum	Not Available	Spectrum

Biological Properties

Cellular Locations

Not Available

Biofluid Locations and Tissue Locations

Ruminal Fluid
Serum

Concentrations

Biofluid	Status	Value	Condition	Species	Reference	Details
Ruminal Fluid	Detected and Quantified	1.02 +/- 0.04 uM	Not Available	Bovine	Saleem F, Bouatra...	details
Serum	Detected and Quantified	4.0838 +/- 3.2922 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	6.18 +/- 3.6443 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	1.9 uM	Not Available	Porcine	Barbara U. Metzle...	details
Serum	Detected and Quantified	2.4 uM	Not Available	Porcine	Barbara U. Metzle...	details
Serum	Detected and Quantified	2.7 uM	Not Available	Porcine	Barbara U. Metzle...	details
Serum	Detected and Quantified	3.9 uM	Not Available	Porcine	Barbara U. Metzle...	details
Serum	Detected and Quantified	4.0627 +/- 2.7803 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	6.4143 +/- 3.835 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	4.2054 +/- 2.3335 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	11.38 +/- 5.62 uM	Not Available	Ovine	Candidate serum m...	details
Serum	Detected and Quantified	6.4916 +/- 2.9845 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	4.5533 +/- 3.2329 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	5.2803 +/- 3.5856 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	5.5804 +/- 3.286 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	4.6349 +/- 3.2179 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	5.4123 +/- 3.4583 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	4.8027 +/- 2.9648 uM	Normal	Ovine	Goldansaz et al.,...	details