Livestock Metabolome Database: Showing metabocard for L-Methionine (LMDB00221)

You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Livestock Metabolome Database.

Identification Taxonomy Ontology Physical properties Spectra Biological properties Concentrations Links References XML

Record Information

Version

1.0

Creation Date

2016-07-13 19:45:02 UTC

Update Date

2021-04-30 20:57:58 UTC

Lmdb

LMDB00221

Secondary Accession Numbers

None

Metabolite Identification

Common Name

L-Methionine

Description

Methionine is a dietary indispensable amino acid required for normal growth and development of animals, other mammals, and avian species. In addition to being a substrate for protein synthesis, it is an intermediate in transmethylation reactions, serving as the major methyl group donor in vivo, including the methyl groups for DNA and RNA intermediates. Methionine is a methyl acceptor for 5-methyltetrahydrofolate-homocysteine methyl transferase (methionine synthase), the only reaction that allows for the recycling of this form of folate, and is also a methyl acceptor for the catabolism of betaine. Methionine is also required for synthesis of cysteine. Methionine is accepted as the metabolic precursor for cysteine. Only the sulfur atom from methionine is transferred to cysteine; the carbon skeleton of cysteine is donated by serine. (PMID 16702340 ). The adequacy range of dietary requirements of specific amino acids in disease states is difficult to determine. Requirements may not be similar in disease with regard to protein synthesis. Requirements for this purpose can be assessed only when such a function can be measured and related to clinical outcome. There is apparent consensus concerning normal sulfur amino acid (SAA) requirements. WHO recommendations amount to 13 mg/kg per 24 h in healthy adults. This amount is roughly doubled in artificial nutrition regimens. In disease or after trauma, requirements may be altered for methionine, cysteine, and taurine. Although in specific cases of congenital enzyme deficiency, prematurity, or diminished liver function, hypermethionemia or hyperhomocysteinemia may occur, SAA supplementation can be considered safe in amounts exceeding 2-3 times the minimal recommended daily intake. Apart from some very specific indications (e.g., acetaminophen poisoning) the usefulness of SAA supplementation is not yet established.(PMID 16702341 ). Methionine is known to exacerbate psychopathological symptoms in schizophrenic patients, there is no evidence of similar effects in healthy subjects. The role of methionine as a precursor of homocysteine is the most notable cause for concern. A "loading dose" of methionine (0.1 g/kg) has been given, and the resultant acute increase in plasma homocysteine has been used as an index of the susceptibility to cardiovascular disease. Although this procedure results in vascular dysfunction, this is acute and unlikely to result in permanent damage. However, a 10-fold larger dose, given mistakenly, resulted in death. Longer-term studies in adults have indicated no adverse consequences of moderate fluctuations in dietary methionine intake, but intakes higher than 5 times normal resulted in elevated homocysteine levels. These effects of methionine on homocysteine and vascular function are moderated by supplements of vitamins B-6, B-12, C, and folic acid. In infants, methionine intakes of 2 to 5 times normal resulted in impaired growth and extremely high plasma methionine levels, but no adverse long-term consequences were observed. (PMID 16702346 ).

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(2S)-2-Amino-4-(methylsulfanyl)butanoic acid	ChEBI
(S)-2-Amino-4-(methylthio)butanoic acid	ChEBI
(S)-2-Amino-4-(methylthio)butyric acid	ChEBI
(S)-Methionine	ChEBI
L-(-)-Methionine	ChEBI
L-alpha-Amino-gamma-methylmercaptobutyric acid	ChEBI
L-Methionin	ChEBI
M	ChEBI
Met	ChEBI
METHIONINE	ChEBI
L-2-Amino-4methylthiobutyric acid	Kegg
L-Methionine Z	Kegg
(2S)-2-Amino-4-(methylsulfanyl)butanoate	Generator
(2S)-2-Amino-4-(methylsulphanyl)butanoate	Generator
(2S)-2-Amino-4-(methylsulphanyl)butanoic acid	Generator
(S)-2-Amino-4-(methylthio)butanoate	Generator
(S)-2-Amino-4-(methylthio)butyrate	Generator
L-a-Amino-g-methylmercaptobutyrate	Generator
L-a-Amino-g-methylmercaptobutyric acid	Generator
L-alpha-Amino-gamma-methylmercaptobutyrate	Generator
L-Α-amino-γ-methylmercaptobutyrate	Generator
L-Α-amino-γ-methylmercaptobutyric acid	Generator
L-2-Amino-4methylthiobutyrate	Generator
(L)-Methionine	HMDB
(S)-(+)-Methionine	HMDB
(S)-2-Amino-4-(methylthio)-butanoate	HMDB
(S)-2-Amino-4-(methylthio)-butanoic acid	HMDB
2-Amino-4-(methylthio)butyrate	HMDB
2-Amino-4-(methylthio)butyric acid	HMDB
2-Amino-4-methylthiobutanoate	HMDB
2-Amino-4-methylthiobutanoic acid	HMDB
a-Amino-g-methylmercaptobutyrate	HMDB
a-Amino-g-methylmercaptobutyric acid	HMDB
Acimethin	HMDB
alpha-Amino-alpha-aminobutyric acid	HMDB
alpha-Amino-gamma-methylmercaptobutyrate	HMDB
alpha-Amino-gamma-methylmercaptobutyric acid	HMDB
Cymethion	HMDB
g-Methylthio-a-aminobutyrate	HMDB
g-Methylthio-a-aminobutyric acid	HMDB
gamma-Methylthio-alpha-aminobutyrate	HMDB
gamma-Methylthio-alpha-aminobutyric acid	HMDB
H-Met-H	HMDB
H-Met-OH	HMDB
L(-)-Amino-alpha-amino-alpha-aminobutyric acid	HMDB
L(-)-Amino-gamma-methylthiobutyric acid	HMDB
L-2-Amino-4-(methylthio)butyric acid	HMDB
L-2-Amino-4-methylthiobutyric acid	HMDB
L-a-Amino-g-methylthiobutyrate	HMDB
L-a-Amino-g-methylthiobutyric acid	HMDB
L-alpha-Amino-gamma-methylthiobutyrate	HMDB
L-alpha-Amino-gamma-methylthiobutyric acid	HMDB
L-gamma-Methylthio-alpha-aminobutyric acid	HMDB
L-Methioninum	HMDB
Liquimeth	HMDB
Mepron	HMDB
Methilanin	HMDB
Methioninum	HMDB
Metionina	HMDB
Neo-methidin	HMDB
Poly-L-methionine	HMDB
Polymethionine	HMDB
S-Methionine	HMDB
S-Methyl-L-homocysteine	HMDB
Toxin war	HMDB
L-Isomer methionine	HMDB
Methionine, L-isomer	HMDB
Pedameth	HMDB
Methionine, L isomer	HMDB
(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-BETA,BETA-carotene-3,3'-diol	ChEBI
Bo-xan	ChEBI
e 161b	ChEBI
Xanthophyll	ChEBI
(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-b,b-carotene-3,3'-diol	Generator
(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-β,β-carotene-3,3'-diol	Generator

Chemical Formula

C₅H₁₁NO₂S

Average Molecular Weight

149.211

Monoisotopic Molecular Weight

149.051049291

IUPAC Name

(2S)-2-amino-4-(methylsulfanyl)butanoic acid

Traditional Name

L-methionine

CAS Registry Number

63-68-3

SMILES

CSCC[C@H](N)C(O)=O

InChI Identifier

InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

InChI Key

FFEARJCKVFRZRR-BYPYZUCNSA-N

Chemical Taxonomy

Description

belongs to the class of organic compounds known as methionine and derivatives. Methionine and derivatives are compounds containing methionine or a derivative thereof resulting from reaction of methionine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Methionine and derivatives

Alternative Parents

Substituents

Methionine or derivatives
Alpha-amino acid
L-alpha-amino acid
Thia fatty acid
Fatty acid
Fatty acyl
Amino acid
Carboxylic acid
Monocarboxylic acid or derivatives
Thioether
Sulfenyl compound
Dialkylthioether
Amine
Organic oxygen compound
Primary amine
Organosulfur compound
Organooxygen compound
Organonitrogen compound
Organic nitrogen compound
Primary aliphatic amine
Carbonyl group
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

aspartate family amino acid (CHEBI:16643 )
proteinogenic amino acid (CHEBI:16643 )
L-alpha-amino acid (CHEBI:16643 )
methionine (CHEBI:16643 )
Common amino acids (C00073 )

Ontology

Status

Detected and Quantified

Origin

Not Available

Biofunction

Not Available

Application

Not Available

Cellular locations

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-1.9	ALOGPS
logP	-2.2	ChemAxon
logS	-0.8	ALOGPS
pKa (Strongest Acidic)	2.53	ChemAxon
pKa (Strongest Basic)	9.5	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	63.32 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	37.59 m³·mol⁻¹	ChemAxon
Polarizability	15.5 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	View
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (2 TMS)	splash10-004i-0920000000-945c85aa7c9f5eb2dfbb	Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (Non-derivatized)	splash10-004i-0910000000-b837ee0f4413856560f1	Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (2 TMS)	splash10-00b9-7910000000-5a1558fbb2f5e86edc9b	Spectrum
GC-MS	GC-MS Spectrum - GC-MS (1 TMS)	splash10-0udi-1900000000-1a97567ce4f25c4e8263	Spectrum
GC-MS	GC-MS Spectrum - GC-MS (2 TMS)	splash10-004i-0910000000-1b0477118cb20549bf4d	Spectrum
GC-MS	GC-MS Spectrum - EI-B (Non-derivatized)	splash10-004i-0920000000-8ffae5d87508e0704903	Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-004i-0920000000-945c85aa7c9f5eb2dfbb	Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-004i-0910000000-b837ee0f4413856560f1	Spectrum
GC-MS	GC-MS Spectrum - GC-EI-QQ (Non-derivatized)	splash10-01bc-2692000000-c6a4af434abaeea2de87	Spectrum
GC-MS	GC-MS Spectrum - GC-EI-TOF (Non-derivatized)	splash10-00b9-7910000000-5a1558fbb2f5e86edc9b	Spectrum
GC-MS	GC-MS Spectrum - GC-MS (Non-derivatized)	splash10-0udi-1900000000-1a97567ce4f25c4e8263	Spectrum
GC-MS	GC-MS Spectrum - GC-MS (Non-derivatized)	splash10-004i-0910000000-1b0477118cb20549bf4d	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-0mbd-9200000000-77e5cfb78936ad02d71c	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (1 TMS) - 70eV, Positive	splash10-00di-9510000000-c03dec8575710eed861e	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_2) - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_1) - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_2) - 70eV, Positive	Not Available	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0uea-1900000000-b991859b2c5bed6592a8	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-08fr-9000000000-66855ace60e59837f131	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-08fr-9000000000-56a567791c824c6a9da6	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0fe0-0900000000-d680295f21b2e2b40366	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0006-9000000000-062d3540db4db22da836	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-00di-0900000000-84467513e2c9ec1a6851	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-88dc2bebb198eea550ef	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0udi-0920000000-b444ad79abeb16acde43	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-6e24a8df417e5f3db58c	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-00di-0900000000-c60ef880eb9a816a274b	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-0900000000-a7b7d1a3481c0c691a5b	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-0002-0900000000-9156f088f4cc9eafa892	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-0002-9200000000-f78ba2aab8d5a0e0b135	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-0002-9000000000-e7b819fd2d0ac3862860	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-0002-9000000000-b61396e720381bd5ff85	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-0002-9000000000-b61396e720381bd5ff85	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-0udi-0900000000-c3557cb41fd6fe268819	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-0udi-6900000000-6bf5af2d1c561013948a	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive	splash10-08fr-9000000000-63c9b1c138f9a27490e5	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive	splash10-03di-9000000000-e133c47b0efe4992589f	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive	splash10-03di-9000000000-dee78b4f34f8732fedb0	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - CE-ESI-TOF (CE-system connected to 6210 Time-of-Flight MS, Agilent) , Positive	splash10-0udi-0900000000-d3f03ff5e8eacc8b6c8e	Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-0udi-0900000000-e0dd5ff44b7962f6a2d2	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0udi-2900000000-305916dde72c899993b6	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0udi-9800000000-47e0a34a2ec02bd762bf	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	1H NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
1D NMR	13C NMR Spectrum	Not Available	Spectrum
2D NMR	[1H,1H] 2D NMR Spectrum	Not Available	Spectrum
2D NMR	[1H,13C] 2D NMR Spectrum	Not Available	Spectrum

Biological Properties

Cellular Locations

Not Available

Biofluid Locations and Tissue Locations

Colostrum
Embryo culture media
Feces
Follicular Fluid
Kidney
Liver
Lung
Meat
Milk
Plasma
Ruminal Fluid
Serum

Concentrations

Biofluid	Status	Value	Condition	Species	Reference	Details
Colostrum	Detected and Quantified	8 uM	Not Available	Bovine	20338431	details
Colostrum	Detected but not Quantified	Not Applicable	Not Available	Bovine	S. F. Graham, T. ...	details
Colostrum	Detected but not Quantified	Not Applicable	Not Available	Bovine	25637742	details
Colostrum	Detected but not Quantified	Not Applicable	Not Available	Bovine	22417363	details
Embryo culture media	Detected but not Quantified	Not Applicable	Not Available	Bovine	20058302	details
Embryo culture media	Detected but not Quantified	Not Applicable	Not Available	Bovine	20058302	details
Feces	Detected but not Quantified	Not Applicable	Not Available	Ovine	17249687	details
Follicular Fluid	Detected and Quantified	31 +/- 1-45+/-1 uM	Not Available	Porcine	183842	details
Kidney	Detected but not Quantified	Not Applicable	Not Available	Porcine	21761043	details
Liver	Detected but not Quantified	Not Applicable	Not Available	Porcine	21761043	details
Lung	Detected but not Quantified	Not Applicable	Not Available	Porcine	23412987	details
Meat	Detected but not Quantified	Not Applicable	Not Available	Bovine	S. F. Graham, T. ...	details
Meat	Detected but not Quantified	Not Applicable	Not Available	Bovine	25637742	details
Meat	Detected but not Quantified	Not Applicable	Not Available	Porcine	24200563	details
Meat	Detected and Quantified	0.79+/-0.10 umol/g	Not Available	Bovine	S. F. Graham, T. ...	details
Meat	Detected and Quantified	0.85+/-0.14 umol/g	Not Available	Bovine	S. F. Graham, T. ...	details
Meat	Detected and Quantified	0.99+/-0.14 umol/g	Not Available	Bovine	S. F. Graham, T. ...	details
Meat	Detected and Quantified	1.08+/-0.19 umol/g	Not Available	Bovine	S. F. Graham, T. ...	details
Meat	Detected but not Quantified	Not Applicable	Not Available	Bovine	22417363	details
Meat	Detected and Quantified	148.53 +/- 22.45 uM	Not Available	Bovine	20831251	details
Meat	Detected and Quantified	151.61 +/- 8.67 uM	Not Available	Bovine	20831251	details
Meat	Detected and Quantified	168.81 +/- 20.31 uM	Not Available	Bovine	20831251	details
Meat	Detected and Quantified	262.51 +/- 12.18 uM	Not Available	Bovine	20831251	details
Milk	Detected but not Quantified	Not Applicable	Not Available	Bovine	23497994	details
Milk	Detected but not Quantified	Not Applicable	Not Available	Bovine	25087032	details
Plasma	Detected and Quantified	32 +/- 1-37+/-4 uM	Not Available	Porcine	22513987	details
Plasma	Detected and Quantified	55 +/- 3-50+/-16 uM	Not Available	Porcine	22513987	details
Plasma	Detected and Quantified	62 +/- 6-49+/-7 uM	Not Available	Porcine	22513987	details
Plasma	Detected and Quantified	16.1 uM	Not Available	Bovine	17197001	details
Plasma	Detected and Quantified	20.8 uM	Not Available	Bovine	17197001	details
Plasma	Detected and Quantified	21.9 uM	Not Available	Bovine	17197001	details
Plasma	Detected and Quantified	20.8-37.7 uM	Not Available	Ovine	17900638	details
Plasma	Detected and Quantified	34.5 +/- 11.34 uM	Not Available	Ovine	17900638	details
Plasma	Detected but not Quantified	Not Applicable	Not Available	Porcine	Sergio Polakof, D...	details
Plasma	Detected but not Quantified	Not Applicable	Not Available	Equine	E. E. Escalona, J...	details
Plasma	Detected but not Quantified	Not Applicable	Not Available	Bovine	22370585	details
Plasma	Detected but not Quantified	Not Applicable	Not Available	Bovine	24630653	details
Plasma	Detected but not Quantified	Not Applicable	Not Available	Ovine	17249687	details
Plasma	Detected but not Quantified	Not Applicable	Not Available	Ovine	22242129	details
Plasma	Detected but not Quantified	Not Applicable	Not Available	Porcine	20231903	details
Plasma	Detected and Quantified	112.01 uM	Not Available	Porcine	25820777	details
Plasma	Detected and Quantified	196.45 uM	Not Available	Porcine	25820777	details
Plasma	Detected and Quantified	207.38 uM	Not Available	Porcine	25820777	details
Plasma	Detected and Quantified	226.36 uM	Not Available	Porcine	25820777	details
Ruminal Fluid	Detected and Quantified	20.6 uM	Not Available	Bovine	22959937	details
Ruminal Fluid	Detected and Quantified	24.6 uM	Not Available	Bovine	22959937	details
Ruminal Fluid	Detected and Quantified	34.6 uM	Not Available	Bovine	22959937	details
Ruminal Fluid	Detected and Quantified	47.1 uM	Not Available	Bovine	22959937	details
Ruminal Fluid	Detected but not Quantified	Not Applicable	Not Available	Bovine	Fozia Saleem, Sou...	details
Ruminal Fluid	Detected and Quantified	19 +/- 10 uM	Not Available	Bovine	Saleem F, Bouatra...	details
Ruminal Fluid	Detected and Quantified	19 +/- 10 uM	Not Available	Bovine	Saleem F, Bouatra...	details
Ruminal Fluid	Detected and Quantified	22 +/- 8 uM	Not Available	Bovine	Saleem F, Bouatra...	details
Ruminal Fluid	Detected and Quantified	32 +/- 10 uM	Not Available	Bovine	Saleem F, Bouatra...	details
Ruminal Fluid	Detected and Quantified	47 +/- 19 uM	Not Available	Bovine	Saleem F, Bouatra...	details
Ruminal Fluid	Detected but not Quantified	Not Applicable	Not Available	Bovine	25599412	details
Serum	Detected and Quantified	33.5721 +/- 10.5732 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	24.6709 +/- 5.2514 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	26.9514 +/- 7.8781 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	33.5897 +/- 7.2751 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	29.2919 +/- 9.5193 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	17.52 +/- 5.25 uM	Not Available	Ovine	Candidate serum m...	details
Serum	Detected and Quantified	27.5128 +/- 8.482 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	27.3309 +/- 5.2309 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	34.0208 +/- 10.4359 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	3.284 uM	Not Available	Porcine	26020888	details
Serum	Detected and Quantified	5.227 uM	Not Available	Porcine	26020888	details
Serum	Detected and Quantified	2.949 uM	Not Available	Porcine	26020888	details
Serum	Detected and Quantified	5.496 uM	Not Available	Porcine	26020888	details
Serum	Detected and Quantified	28.3902 +/- 9.6015 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	24.7783 +/- 8.942 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	0.00664 +/- 0.000684 uM	Not Available	Porcine	19847666	details
Serum	Detected and Quantified	0.00405 +/- 0.000556 uM	Not Available	Porcine	19847666	details
Serum	Detected and Quantified	31.8764 +/- 9.2824 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	35.025 +/- 11.0368 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	40 +/- 3 uM	Not Available	Porcine	183842	details
Serum	Detected and Quantified	27.3703 +/- 10.141 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected but not Quantified	Not Applicable	Not Available	Porcine	21942754	details
Serum	Detected but not Quantified	Not Applicable	Not Available	Porcine	18989615	details
Serum	Detected but not Quantified	Not Applicable	Not Available	Porcine	23255817	details
Serum	Detected but not Quantified	Not Applicable	Not Available	Porcine	26020888	details
Serum	Detected but not Quantified	Not Applicable	Not Available	Porcine	21584308	details
Serum	Detected but not Quantified	Not Applicable	Not Available	Bovine	25372282	details
Serum	Detected but not Quantified	Not Applicable	Not Available	Bovine	25372282	details
Serum	Detected and Quantified	33.0114 +/- 9.1957 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected but not Quantified	Not Applicable	Not Available	Bovine	25372282	details
Serum	Detected and Quantified	29.0423 +/- 8.0934 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected but not Quantified	Not Applicable	Not Available	Porcine	21761043	details
Serum	Detected but not Quantified	Not Applicable	Not Available	Porcine	21429726	details
Serum	Detected and Quantified	24.6377 +/- 8.5954 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected but not Quantified	Not Applicable	Not Available	Caprine	24214495	details
Serum	Detected but not Quantified	Not Applicable	Not Available	Caprine	24214495	details
Serum	Detected and Quantified	25.1111 +/- 6.9614 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	33.9517 +/- 12.4149 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	27.6832 +/- 6.7664 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	27.4964 +/- 9.2128 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	34.32 uM	Not Available	Porcine	Barbara U. Metzle...	details
Serum	Detected and Quantified	47.9 uM	Not Available	Porcine	Barbara U. Metzle...	details
Serum	Detected and Quantified	56.61 uM	Not Available	Porcine	Barbara U. Metzle...	details
Serum	Detected and Quantified	64.9 uM	Not Available	Porcine	Barbara U. Metzle...	details

External Links

DrugBank ID

DB00134

HMDB ID

HMDB0000696

FooDB ID

FDB012683

Phenol Explorer ID

Not Available

KNApSAcK ID

BiGG ID

BioCyc ID

METLIN ID

PDB ID

Not Available

Wikipedia Link

Chemspider ID

ChEBI ID

PubChem Compound ID

Kegg Compound ID

YMDB ID

ECMDB ID

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Not Available

General References

Ball RO, Courtney-Martin G, Pencharz PB: The in vivo sparing of methionine by cysteine in sulfur amino acid requirements in animal models and adult humans. J Nutr. 2006 Jun;136(6 Suppl):1682S-1693S. [16702340 ]
van de Poll MC, Dejong CH, Soeters PB: Adequate range for sulfur-containing amino acids and biomarkers for their excess: lessons from enteral and parenteral nutrition. J Nutr. 2006 Jun;136(6 Suppl):1694S-1700S. [16702341 ]
Garlick PJ: Toxicity of methionine in humans. J Nutr. 2006 Jun;136(6 Suppl):1722S-1725S. [16702346 ]

Showing metabocard for L-Methionine (LMDB00221)

Structure for LMDB00221 (L-Methionine)