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Record Information
Version1.0
Creation Date2016-07-13 19:53:43 UTC
Update Date2016-07-19 23:33:12 UTC
LmdbLMDB00611
Secondary Accession NumbersNone
Metabolite Identification
Common NamePC(o-20:0/20:4(8Z,11Z,14Z,17Z))
DescriptionPC(o-20:0/20:4(8Z,11Z,14Z,17Z)) is a phosphatidylcholine (PC or GPCho). It is a glycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, glycerophosphocholines can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PC(o-20:0/20:4(8Z,11Z,14Z,17Z)), in particular, consists of one chain of Arachidyl alcohol at the C-1 position and one chain of eicosatetraenoic acid at the C-2 position. The Arachidyl alcohol moiety is derived from corn oil, while the eicosatetraenoic acid moiety is derived from fish oils. Phospholipids, are ubiquitous in nature and are key components of the lipid bilayer of cells, as well as being involved in metabolism and signaling. While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. PCs can be synthesized via three different routes. In one route, choline is activated first by phosphorylation and then by coupling to CDP prior to attachment to phosphatidic acid. PCs can also synthesized by the addition of choline to CDP-activated 1,2-diacylglycerol. A third route to PC synthesis involves the conversion of either PS or PE to PC.
Structure
Thumb
Synonyms
ValueSource
PC(o-20:0/20:4(8Z,11Z,14Z,17Z))Lipid Annotator
GPCho(20:0/20:4)Lipid Annotator, HMDB
PC(20:0/20:4)Lipid Annotator, HMDB
Phosphatidylcholine(40:4)Lipid Annotator, HMDB
LecithinLipid Annotator, HMDB
Phosphatidylcholine(20:0/20:4)Lipid Annotator, HMDB
GPCho(40:4)Lipid Annotator, HMDB
1-Arachidyl-2-eicsoatetraenoyl-sn-glycero-3-phosphocholineLipid Annotator, HMDB
1-eicosanyl-2-(8Z,11Z,14Z,17Z-eicosapentaenoyl)-sn-glycero-3-phosphocholineLipid Annotator, HMDB
PC(40:4)Lipid Annotator, HMDB
1-Arachidyl-2-eicsoateHMDB
1-Arachidyl-2-eicsoic acidHMDB
gpcho(20:0/20:4n3)HMDB
gpcho(20:0/20:4W3)HMDB
PC Ae C40:4HMDB
PC(20:0/20:4n3)HMDB
PC(20:0/20:4W3)HMDB
PC(O-40:4)HMDB
Phosphatidylcholine(20:0/20:4n3)HMDB
Phosphatidylcholine(20:0/20:4W3)HMDB
Chemical FormulaC48H90NO7P
Average Molecular Weight824.2045
Monoisotopic Molecular Weight823.645490751
IUPAC Name(2-{[(2R)-2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]-3-(icosyloxy)propyl phosphono]oxy}ethyl)trimethylazanium
Traditional Name(2-{[(2R)-2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]-3-(icosyloxy)propyl phosphono]oxy}ethyl)trimethylazanium
CAS Registry NumberNot Available
SMILES
CCCCCCCCCCCCCCCCCCCCOC[C@]([H])(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC
InChI Identifier
InChI=1S/C48H90NO7P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-40-43-53-45-47(46-55-57(51,52)54-44-42-49(3,4)5)56-48(50)41-39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h15,17,21,23,27,29,33,35,47H,6-14,16,18-20,22,24-26,28,30-32,34,36-46H2,1-5H3/b17-15-,23-21-,29-27-,35-33-/t47-/m1/s1
InChI KeyRDNHPNJCALITSY-MBZSPAKGSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as 1-alkyl,2-acylglycero-3-phosphocholines. These are glycerophosphocholines that carry exactly one acyl chain attached to the glycerol moiety through an ester linkage at the O2-position, and one alkyl chain attached through an ether linkage at the O1-position.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassGlycerophospholipids
Sub ClassGlycerophosphocholines
Direct Parent1-alkyl,2-acylglycero-3-phosphocholines
Alternative Parents
Substituents
  • 1-alkyl,2-acylglycero-3-phosphocholine
  • Phosphocholine
  • Fatty acid ester
  • Dialkyl phosphate
  • Glycerol ether
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Fatty acyl
  • Alkyl phosphate
  • Tetraalkylammonium salt
  • Quaternary ammonium salt
  • Carboxylic acid ester
  • Carboxylic acid derivative
  • Dialkyl ether
  • Ether
  • Monocarboxylic acid or derivatives
  • Organonitrogen compound
  • Organopnictogen compound
  • Organic oxygen compound
  • Carbonyl group
  • Amine
  • Organic nitrogen compound
  • Organooxygen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organic salt
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
StatusDetected and Quantified
OriginNot Available
BiofunctionNot Available
ApplicationNot Available
Cellular locationsNot Available
Physical Properties
StateNot Available
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP6.67ALOGPS
logP10.6ChemAxon
logS-7.5ALOGPS
pKa (Strongest Acidic)1.86ChemAxon
pKa (Strongest Basic)-4.1ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area94.12 ŲChemAxon
Rotatable Bond Count44ChemAxon
Refractivity257.38 m³·mol⁻¹ChemAxon
Polarizability102.79 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-00di-0000000090-de220e58893f382072b8Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-00di-0000000090-de220e58893f382072b8Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0089-1900061160-42a389ce5d5214f6411cSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-00di-0000000090-86cf1871415afecc1f61Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-00di-0032002390-68c13e11746a7ca61258Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0udj-8189300000-d2a1f56835e4b777240eSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0a4i-0000000090-35b0cc58318f5250b758Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0a4i-0000000090-35b0cc58318f5250b758Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0udj-0007120920-3cab358b716eb15e0652Spectrum
Biological Properties
Cellular LocationsNot Available
Biofluid Locations and Tissue Locations
  • Plasma
  • Serum
Concentrations
BiofluidStatusValueConditionSpeciesReferenceDetails
PlasmaDetected and Quantified1.6566 +/- 0.2115-1.6691+/-0.2115 uMNot AvailablePorcine details
PlasmaDetected and Quantified1.9263 +/- 0.2291-1.4963+/-0.2291 uMNot AvailablePorcine details
SerumDetected and Quantified2 uMNot AvailablePorcine
    • Barbara U. Metzle...
details
SerumDetected and Quantified2.2 uMNot AvailablePorcine
    • Barbara U. Metzle...
details
SerumDetected and Quantified1.2 uMNot AvailablePorcine
    • Barbara U. Metzle...
details
SerumDetected and Quantified1.8 uMNot AvailablePorcine
    • Barbara U. Metzle...
details
DrugBank IDNot Available
HMDB IDHMDB0013442
FooDB IDFDB029442
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkNot Available
Chemspider ID35032625
ChEBI IDNot Available
PubChem Compound ID52923852
Kegg Compound IDNot Available
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available