Livestock Metabolome Database: Showing metabocard for Potassium (LMDB00185)

Identification Taxonomy Ontology Physical properties Spectra Biological properties Concentrations Links References XML

Record Information

Version

1.0

Creation Date

2016-07-13 19:44:13 UTC

Update Date

2020-03-13 18:12:29 UTC

Lmdb

LMDB00185

Secondary Accession Numbers

None

Metabolite Identification

Common Name

Potassium

Description

Potassium is an essential electrolyte. Potassium balance is crucial for regulating the excitability of nerves and muscles and so critical for regulating contractility of cardiac muscle. Although the most important changes seen in the presence of deranged potassium are cardiac, smooth muscle is also affected with increasing muscle weakness, a feature of both hyperkalaemia and hypokalaemia. Physiologically, it exists as an ion in the body. Potassium (K+) is a positively charged electrolyte, cation, which is present throughout the body in both intracellular and extracellular fluids. The majority of body potassium, >90%, are intracellular. It moves freely from intracellular fluid (ICF) to extracellular fluid (ECF) and vice versa when adenosine triphosphate increases the permeability of the cell membrane. It is mainly replaced inside or outside the cells by another cation, sodium (Na+). The movement of potassium into or out of the cells is linked to certain body hormones and also to certain physiological states. Standard laboratory tests measure ECF potassium. Potassium enters the body rapidly during food ingestion. Insulin is produced when a meal is eaten; this causes the temporary movement of potassium from ECF to ICF. Over the ensuing hours, the kidneys excrete the ingested potassium and homeostasis is returned. In the critically ill patient, suffering from hyperkalaemia, this mechanism can be manipulated beneficially by administering high concentration (50%) intravenous glucose. Insulin can be added to the glucose, but glucose alone will stimulate insulin production and cause movement of potassium from ECF to ICF. The stimulation of alpha receptors causes increased movement of potassium from ICF to ECF. A noradrenaline infusion can elevate serum potassium levels. An adrenaline infusion, or elevated adrenaline levels, can lower serum potassium levels. Metabolic acidosis causes a rise in extracellular potassium levels. In this situation, excess of hydrogen ions (H+) are exchanged for intracellular potassium ions, probably as a result of the cellular response to a falling blood pH. Metabolic alkalosis causes the opposite effect, with potassium moving into the cells. (PMID: 17883675 ).

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
K(+)	ChEBI
K+	ChEBI
POTASSIUM ion	ChEBI
Potassium(1+)	Kegg
Nabumeton a	Kegg
Kalium	HMDB
Potassium (ion)	HMDB
Potassium (k+)	HMDB
Potassium cation	HMDB
Potassium ion (k+)	HMDB
Potassium ion (K1+)	HMDB
Potassium ion(+)	HMDB
Potassium ion(1+)	HMDB
Potassium monocation	HMDB
Potassium(+)	HMDB
Potassium(1+) ion	HMDB
Potassium(I) cation	HMDB
Liver regeneration factor 1	HMDB
LRF-1	HMDB
LRF1 Transcription factor	HMDB

Chemical Formula

Average Molecular Weight

39.0983

Monoisotopic Molecular Weight

38.963706861

IUPAC Name

potassium(1+) ion

Traditional Name

potassium(1+) ion

CAS Registry Number

7440-09-7

SMILES

[K+]

InChI Identifier

InChI=1S/K/q+1

InChI Key

NPYPAHLBTDXSSS-UHFFFAOYSA-N

Chemical Taxonomy

Description

belongs to the class of inorganic compounds known as homogeneous alkali metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkali metal atom.

Kingdom

Inorganic compounds

Super Class

Homogeneous metal compounds

Class

Homogeneous alkali metal compounds

Sub Class

Not Available

Direct Parent

Homogeneous alkali metal compounds

Alternative Parents

Not Available

Substituents

Homogeneous alkali metal

Molecular Framework

Not Available

External Descriptors

elemental potassium (CHEBI:29103 )
alkali metal cation (CHEBI:29103 )
monovalent inorganic cation (CHEBI:29103 )
monoatomic monocation (CHEBI:29103 )
a cation (K+ )

Ontology

Status

Detected and Quantified

Origin

Not Available

Biofunction

Not Available

Application

Not Available

Cellular locations

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	0.2	ChemAxon
pKa (Strongest Acidic)	3.09	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	0 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	0 m³·mol⁻¹	ChemAxon
Polarizability	1.78 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-000i-9000000000-560fc6f738e9570ec8a2	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-000i-9000000000-560fc6f738e9570ec8a2	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-000i-9000000000-560fc6f738e9570ec8a2	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-000i-9000000000-bcbe5ea7d5d32f6a9598	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-000i-9000000000-bcbe5ea7d5d32f6a9598	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-000i-9000000000-bcbe5ea7d5d32f6a9598	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-000i-9000000000-e11fed6c31524d9e4d2c	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-000i-9000000000-e11fed6c31524d9e4d2c	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-000i-9000000000-e11fed6c31524d9e4d2c	Spectrum

Biological Properties

Cellular Locations

Not Available

Biofluid Locations and Tissue Locations

Follicular Fluid
Milk
Plasma
Ruminal Fluid
Serum

Concentrations

Biofluid	Status	Value	Condition	Species	Reference	Details
Follicular Fluid	Detected and Quantified	8184.499 uM	Not Available	Bovine	C. Lutwak-Mann. N...	details
Follicular Fluid	Detected and Quantified	2600 +/- 2000 uM	Not Available	Porcine	183842	details
Milk	Detected and Quantified	1060 mg/kg	Not Available	Ovine	22004605	details
Milk	Detected and Quantified	1090 mg/kg	Not Available	Ovine	22004605	details
Milk	Detected and Quantified	1120 mg/kg	Not Available	Ovine	22004605	details
Milk	Detected and Quantified	1120 mg/kg	Not Available	Ovine	22004605	details
Milk	Detected and Quantified	1140 mg/kg	Not Available	Ovine	22004605	details
Milk	Detected and Quantified	1140 mg/kg	Not Available	Ovine	22004605	details
Milk	Detected and Quantified	1990-2020 mg/kg	Not Available	Caprine	24704223	details
Milk	Detected and Quantified	2000 mg/kg	Not Available	Caprine	24704223	details
Milk	Detected and Quantified	1930-2000 mg/kg	Not Available	Caprine	24704223	details
Milk	Detected and Quantified	1910-2090 mg/kg	Not Available	Caprine	24704223	details
Milk	Detected and Quantified	1520 mg/kg	Not Available	Bovine	Park, Y. W; Juáre...	details
Milk	Detected and Quantified	1360 mg/kg	Not Available	Ovine	Park, Y. W; Juáre...	details
Milk	Detected and Quantified	1810 mg/kg	Not Available	Caprine	Park, Y. W; Juáre...	details
Milk	Detected and Quantified	1370 mg/kg	Not Available	Bovine	9718493	details
Milk	Detected and Quantified	1480 mg/kg	Not Available	Bovine	9718493	details
Milk	Detected and Quantified	1480 mg/kg	Not Available	Bovine	9718493	details
Milk	Detected and Quantified	1520 mg/kg	Not Available	Bovine	9718493	details
Milk	Detected and Quantified	1520 mg/kg	Not Available	Bovine	9718493	details
Milk	Detected and Quantified	1540 mg/kg	Not Available	Bovine	9718493	details
Milk	Detected and Quantified	1570 mg/kg	Not Available	Bovine	9718493	details
Milk	Detected and Quantified	1590 mg/kg	Not Available	Bovine	9718493	details
Milk	Detected and Quantified	1590 mg/kg	Not Available	Bovine	9718493	details
Milk	Detected and Quantified	1590 mg/kg	Not Available	Bovine	9718493	details
Milk	Detected and Quantified	1590 mg/kg	Not Available	Bovine	9718493	details
Milk	Detected and Quantified	1610 mg/kg	Not Available	Bovine	9718493	details
Plasma	Detected and Quantified	2890 +/- 190 uM	Not Available	Bovine	Abdullah BAŞOĞLU,...	details
Plasma	Detected and Quantified	3050 +/- 100 uM	Not Available	Bovine	Abdullah BAŞOĞLU,...	details
Plasma	Detected and Quantified	3810 +/- 80 uM	Not Available	Bovine	Abdullah BAŞOĞLU,...	details
Ruminal Fluid	Detected and Quantified	27264.613 uM	Not Available	Ovine	M.L.K. Bonsi, P.O...	details
Ruminal Fluid	Detected and Quantified	34681.815-39490.208 uM	Not Available	Ovine	M.L.K. Bonsi, P.O...	details
Ruminal Fluid	Detected and Quantified	35167.769-38313.686 uM	Not Available	Ovine	M.L.K. Bonsi, P.O...	details
Ruminal Fluid	Detected and Quantified	27,333 uM	Not Available	Bovine	Saleem F, Bouatra...	details
Ruminal Fluid	Detected and Quantified	18,120 +/- 153 uM	Not Available	Bovine	Saleem F, Bouatra...	details
Serum	Detected and Quantified	6042.27 +/- 1156.96 uM	Not Available	Ovine	Candidate serum m...	details
Serum	Detected and Quantified	7100 +/- 400 uM	Not Available	Porcine	183842	details
Serum	Detected and Quantified	4650 uM	Not Available	Bovine	2286555	details
Serum	Detected and Quantified	4710 uM	Not Available	Bovine	2286555	details