Record Information |
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Version | 1.0 |
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Creation Date | 2016-07-13 19:49:03 UTC |
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Update Date | 2016-07-19 23:26:32 UTC |
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Lmdb | LMDB00402 |
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Secondary Accession Numbers | None |
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Metabolite Identification |
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Common Name | Nickel |
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Description | Nickel is a solid, silver-white, hard, malleable transition metal with an atomic number of 28. It resists corrosion even at high temperatures. It is present in many alloys in widespread use, including stainless steels. It may also be present as an impurity in any alloy. Nickel is used in the production of coins, jewellery, and nickel-cadmium batteries, and as a catalyst for the hydrogenation of liquid oils to solid fats such as oleomargarine and vegetable shortening. Nickel-containing dental alloys continue to be used successfully in the provision of various forms of dental care. Many of these alloys have applications in the construction of restorations designed to remain in clinical service for many years, including crowns, fixed bridgework, and removable partial dentures. Furthermore, nickel containing alloys find extensive application in orthodontics, including metallic brackets, arch wires, bands, springs and ligature wires. Many instruments and devises, for example, endodontic instruments also contain nickel. Allergic responses are mediated through the immune system. In a sensitized individual, allergic responses can be initiated by relatively small amounts of the allergen; for example, if nickel ions are released from a nickel plated material following direct and prolonged contact with the skin. Individuals are first sensitized to the allergen. Subsequent exposures, if sufficiently high, may then result in an allergic reaction. A number of allergens are used in the clinical practice of dentistry, notably eugenol, mercury, nickel, chromium, cobalt, components of resin-based materials and a host of other chemical agents. The majority of dental allergies, including allergic responses to nickel-containing dental alloys, comprise Type IV hypersensitivity reactions, cell-mediated by T-lymphocytes. Physiologically, it exists as an ion in the body.(PMID: 17243350 , 16405986 ). |
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Structure | |
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Synonyms | Value | Source |
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Ni2+ | ChEBI | Ni(2+) | ChEBI | NICKEL (II) ion | ChEBI | Nickel, ion (ni2+) | ChEBI | Nickelous ion | ChEBI | Ni(II) | Kegg | Carbonyl nickel powder | HMDB | Malleable nickel | HMDB | NI | HMDB | Nichel | HMDB | Nickel 200 | HMDB | Nickel 201 | HMDB | Nickel 204 | HMDB | Nickel 205 | HMDB | Nickel 211 | HMDB | Nickel 212 | HMDB | Nickel 213 | HMDB | Nickel 222 | HMDB | Nickel 223 | HMDB | Nickel 229 | HMDB | Nickel 270 | HMDB | Nickel particles | HMDB | Nickel sponge | HMDB | Raney alloy | HMDB | Raney nickel | HMDB |
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Chemical Formula | Ni |
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Average Molecular Weight | 58.6934 |
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Monoisotopic Molecular Weight | 57.935347922 |
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IUPAC Name | nickel(2+) ion |
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Traditional Name | nickel(2+) ion |
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CAS Registry Number | 7440-02-0 |
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SMILES | [Ni++] |
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InChI Identifier | InChI=1S/Ni/q+2 |
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InChI Key | VEQPNABPJHWNSG-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom. |
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Kingdom | Inorganic compounds |
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Super Class | Homogeneous metal compounds |
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Class | Homogeneous transition metal compounds |
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Sub Class | Not Available |
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Direct Parent | Homogeneous transition metal compounds |
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Alternative Parents | |
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Substituents | - Homogeneous transition metal
- Inorganic nickel compound
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Molecular Framework | Not Available |
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External Descriptors | |
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Ontology |
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Status | Detected and Quantified |
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Origin | Not Available |
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Biofunction | Not Available |
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Application | Not Available |
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Cellular locations | Not Available |
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Physical Properties |
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State | Not Available |
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Experimental Properties | Property | Value | Reference |
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Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Predicted Properties | |
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Spectra |
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Spectra | Spectrum Type | Description | Splash Key | View |
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Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-0a4i-9000000000-08256b3c9e2cc1750f60 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-0a4i-9000000000-08256b3c9e2cc1750f60 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0a4i-9000000000-08256b3c9e2cc1750f60 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-0a4i-9000000000-4648ffc6f53552c41503 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-0a4i-9000000000-4648ffc6f53552c41503 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0a4i-9000000000-4648ffc6f53552c41503 | Spectrum |
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General References | - Hostynek JJ: Sensitization to nickel: etiology, epidemiology, immune reactions, prevention, and therapy. Rev Environ Health. 2006 Oct-Dec;21(4):253-80. [17243350 ]
- Setcos JC, Babaei-Mahani A, Silvio LD, Mjor IA, Wilson NH: The safety of nickel containing dental alloys. Dent Mater. 2006 Dec;22(12):1163-8. Epub 2006 Jan 6. [16405986 ]
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