Record Information |
---|
Version | 1.0 |
---|
Creation Date | 2016-07-13 19:50:14 UTC |
---|
Update Date | 2016-08-01 19:11:18 UTC |
---|
Lmdb | LMDB00455 |
---|
Secondary Accession Numbers | None |
---|
Metabolite Identification |
---|
Common Name | Estrone glucuronide |
---|
Description | Estrone-glucuronide is the dominant metabolite of estradiol. Estrone glucuronide is formed by a UDP glucuronyltransferase (EC 2.4.1.17, UTP) reaction creating a much more water-soluble form of the hormone; glucuronides are the most abundant estrogen conjugates. Measurement of estrone-glucuronide is used as one reference method for determining ovulation (immunotubes are available for measuring urinary estrone glucuronide in conjunction with LH, one of the most advanced of ovulation prediction products). (PMID: 14742773 , 1755456 ). |
---|
Structure | |
---|
Synonyms | Value | Source |
---|
Estrone 3-glucosiduronic acid | ChEBI | Estrone 3-glucuronide | ChEBI | Estrone beta-D-glucuronide | ChEBI | Estrone 3-glucosiduronate | Generator | Estrone b-D-glucuronide | Generator | Estrone β-D-glucuronide | Generator | Estrone beta-delta-glucuronide | HMDB | Estrone-3-glucosiduronic acid | HMDB | Estrone-3-glucuronide | HMDB | Estrone-3-glucosiduronate | HMDB |
|
---|
Chemical Formula | C24H30O8 |
---|
Average Molecular Weight | 446.4902 |
---|
Monoisotopic Molecular Weight | 446.194067936 |
---|
IUPAC Name | (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-{[(1S,10R,11S,15S)-15-methyl-14-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-2,4,6-trien-5-yl]oxy}oxane-2-carboxylic acid |
---|
Traditional Name | estrone-3-glucuronide |
---|
CAS Registry Number | 2479-90-5 |
---|
SMILES | [H][C@@]12CCC(=O)[C@@]1(C)CC[C@]1([H])C3=CC=C(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)C(O)=O)C=C3CC[C@@]21[H] |
---|
InChI Identifier | InChI=1S/C24H30O8/c1-24-9-8-14-13-5-3-12(10-11(13)2-4-15(14)16(24)6-7-17(24)25)31-23-20(28)18(26)19(27)21(32-23)22(29)30/h3,5,10,14-16,18-21,23,26-28H,2,4,6-9H2,1H3,(H,29,30)/t14-,15-,16+,18+,19+,20-,21+,23-,24+/m1/s1 |
---|
InChI Key | FJAZVHYPASAQKM-JBAURARKSA-N |
---|
Chemical Taxonomy |
---|
Description | belongs to the class of organic compounds known as steroid glucuronide conjugates. These are sterol lipids containing a glucuronide moiety linked to the steroid skeleton. |
---|
Kingdom | Organic compounds |
---|
Super Class | Lipids and lipid-like molecules |
---|
Class | Steroids and steroid derivatives |
---|
Sub Class | Steroidal glycosides |
---|
Direct Parent | Steroid glucuronide conjugates |
---|
Alternative Parents | |
---|
Substituents | - Steroid-glucuronide-skeleton
- Estrane-skeleton
- 17-oxosteroid
- Oxosteroid
- Fatty acyl glycoside
- Fatty acyl glycoside of mono- or disaccharide
- Phenolic glycoside
- 1-o-glucuronide
- O-glucuronide
- Phenanthrene
- Glucuronic acid or derivatives
- Alkyl glycoside
- Glycosyl compound
- O-glycosyl compound
- Tetralin
- Beta-hydroxy acid
- Pyran
- Fatty acyl
- Oxane
- Benzenoid
- Monosaccharide
- Hydroxy acid
- Ketone
- Secondary alcohol
- Oxacycle
- Organoheterocyclic compound
- Polyol
- Carboxylic acid derivative
- Carboxylic acid
- Acetal
- Monocarboxylic acid or derivatives
- Hydrocarbon derivative
- Organic oxygen compound
- Carbonyl group
- Alcohol
- Organic oxide
- Organooxygen compound
- Aromatic heteropolycyclic compound
|
---|
Molecular Framework | Aromatic heteropolycyclic compounds |
---|
External Descriptors | |
---|
Ontology |
---|
Status | Detected but not Quantified |
---|
Origin | Not Available |
---|
Biofunction | Not Available |
---|
Application | Not Available |
---|
Cellular locations | Not Available |
---|
Physical Properties |
---|
State | Not Available |
---|
Experimental Properties | Property | Value | Reference |
---|
Melting Point | Not Available | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
|
---|
Predicted Properties | |
---|
Spectra |
---|
Spectra | Spectrum Type | Description | Splash Key | View |
---|
Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | splash10-056r-8219500000-6befcfde02b865659c65 | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (3 TMS) - 70eV, Positive | splash10-0002-4222229000-9df02b5eaa81482e1d84 | Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive | Not Available | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - , negative | splash10-00kb-0150900000-dbbdbeaeaa0fb7b65b0c | Spectrum | LC-MS/MS | LC-MS/MS Spectrum - LC-ESI-QFT , negative | splash10-00kb-0150900000-78a9ec4beb4fe22a8735 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-00fs-0190700000-ab622d54514a7c8dd7bb | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-00di-0390000000-0ca06f8d5f8e2266eca1 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0fmi-0890000000-33ca823ccbdc77eec8b9 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-00kb-1252900000-1603a7df81c822d36ace | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-014i-1291100000-aea6098c09be50c7aeb7 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-014i-3190000000-c37a96962dc8073839bc | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Positive | splash10-006t-0090800000-ac0903dfe69104eaa019 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Positive | splash10-01xt-0333900000-4ad5c8540eff279f8192 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Positive | splash10-0cg0-2934000000-4ee88a34dbe6cd0e8b57 | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 10V, Negative | splash10-0002-0000900000-dfac460c786c0c82c3be | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 20V, Negative | splash10-014j-6591800000-28870ff9517fe62979be | Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - 40V, Negative | splash10-0aor-7091200000-0d8562a190cdb0c97cc6 | Spectrum |
|
---|