Livestock Metabolome Database: Showing metabocard for SM(d18:0/14:1(9Z)(OH)) (LMDB00624)

Identification Taxonomy Ontology Physical properties Spectra Biological properties Concentrations Links References XML

Record Information

Version

1.0

Creation Date

2016-07-13 19:54:00 UTC

Update Date

2021-04-30 20:57:40 UTC

Lmdb

LMDB00624

Secondary Accession Numbers

None

Metabolite Identification

Common Name

SM(d18:0/14:1(9Z)(OH))

Description

Sphingomyelin (d18:0/14:1(9Z)(OH)) or SM(d18:0/14:1(9Z)(OH)) is a type of sphingolipid found in animal cell membranes, especially in the membranous myelin sheath which surrounds some nerve cell axons. It usually consists of phosphorylcholine and ceramide. In animals, sphingomyelin is the only membrane phospholipid not derived from glycerol. Like all sphingolipids, SPH has a ceramide core (sphingosine bonded to a fatty acid via an amide linkage). In addition it contains one polar head group, which is either phosphocholine or phosphoethanolamine. The plasma membrane of cells is highly enriched in sphingomyelin and is considered largely to be found in the exoplasmic leaflet of the cell membrane. However, there is some evidence that there may also be a sphingomyelin pool in the inner leaflet of the membrane. Moreover, neutral sphingomyelinase-2 - an enzyme that breaks down sphingomyelin into ceramide has been found to localise exclusively to the inner leaflet further suggesting that there may be sphingomyelin present there. Sphingomyelin can accumulate in a rare hereditary disease called Niemann-Pick Disease, types A and B. Niemann-Pick disease is a genetically-inherited disease caused by a deficiency in the enzyme Sphingomyelinase, which causes the accumulation of Sphingomyelin in spleen, liver, lungs, bone marrow, and the brain, causing irreversible neurological damage. SMs play a role in signal transduction. Sphingomyelins are synthesized by the transfer of phosphorylcholine from phosphatidylcholine to a ceramide in a reaction catalyzed by sphingomyelin synthase.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
C14:1-OH Sphingomyelin	ChEBI
Hydroxysphingomyeline C14:1	ChEBI
N-[(9Z)-3-Hydroxytetradec-9-enoyl]sphing-4-enine-1-phosphocholine	ChEBI
SM(D18:1/14:1(9Z)(OH))	ChEBI
N-(15Z-Tetracosenoyl)-sphing-4-enine-1-phosphocholine	HMDB
Sphingomyelin	MetBuilder
N-(3-Hydroxy-9Z-tetradecenoyl)-1-phosphocholine-sphinganine	MetBuilder
Sphingomyelin(D18:0/14:1(9Z)(OH))	MetBuilder
N-(3-Hydroxy-9Z-tetradecenoyl)-1-phosphocholine-dihydrosphingosine	MetBuilder
N-(3-Hydroxy-9Z-tetradecenoyl)-1-phosphocholine-D-erythro-sphinganine	MetBuilder

Chemical Formula

C₃₇H₇₃N₂O₇P

Average Molecular Weight

688.9585

Monoisotopic Molecular Weight

688.515539212

IUPAC Name

(2-{[(2S,3R,4E)-3-hydroxy-2-[(9Z)-3-hydroxytetradec-9-enamido]octadec-4-en-1-yl phosphono]oxy}ethyl)trimethylazanium

Traditional Name

(2-{[(2S,3R,4E)-3-hydroxy-2-[(9Z)-3-hydroxytetradec-9-enamido]octadec-4-en-1-yl phosphono]oxy}ethyl)trimethylazanium

CAS Registry Number

Not Available

SMILES

CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](COP([O-])(=O)OCC[N+](C)(C)C)NC(=O)CC(O)CCCCC\C=C/CCCC

InChI Identifier

InChI=1S/C37H73N2O7P/c1-6-8-10-12-14-16-17-18-19-21-23-25-27-29-36(41)35(33-46-47(43,44)45-31-30-39(3,4)5)38-37(42)32-34(40)28-26-24-22-20-15-13-11-9-7-2/h13,15,27,29,34-36,40-41H,6-12,14,16-26,28,30-33H2,1-5H3,(H-,38,42,43,44)/b15-13-,29-27+/t34?,35-,36+/m0/s1

InChI Key

ZNHNJXWKKQKMBU-POWUNZFVSA-N

Chemical Taxonomy

Description

belongs to the class of organic compounds known as phosphosphingolipids. These are sphingolipids with a structure based on a sphingoid base that is attached to a phosphate head group. They differ from phosphonospingolipids which have a phosphonate head group.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Sphingolipids

Sub Class

Phosphosphingolipids

Direct Parent

Phosphosphingolipids

Alternative Parents

Substituents

Sphingoid-1-phosphate or derivatives
Phosphocholine
Phosphoethanolamine
Dialkyl phosphate
Fatty amide
N-acyl-amine
Organic phosphoric acid derivative
Phosphoric acid ester
Fatty acyl
Alkyl phosphate
Tetraalkylammonium salt
Quaternary ammonium salt
Secondary carboxylic acid amide
Secondary alcohol
Carboxamide group
Carboxylic acid derivative
Organic zwitterion
Alcohol
Organic oxide
Organooxygen compound
Organonitrogen compound
Organopnictogen compound
Organic oxygen compound
Organic nitrogen compound
Hydrocarbon derivative
Carbonyl group
Amine
Organic salt
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

Not Available

Ontology

Status

Detected and Quantified

Origin

Not Available

Biofunction

Not Available

Application

Not Available

Cellular locations

Not Available

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	3.91	ALOGPS
logP	4.49	ChemAxon
logS	-7.1	ALOGPS
pKa (Strongest Acidic)	1.86	ChemAxon
pKa (Strongest Basic)	-1.5	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	128.15 Å²	ChemAxon
Rotatable Bond Count	33	ChemAxon
Refractivity	207.37 m³·mol⁻¹	ChemAxon
Polarizability	82.81 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-0072-6540659000-3b08a67bb8852b6cfae7	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_1) - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_2) - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_1_3) - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_1) - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_2) - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TMS_2_3) - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_1) - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_2) - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (TBDMS_1_3) - 70eV, Positive	Not Available	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-000i-7030958000-66754a93f8529338328d	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0019-2150941000-f1cacae6bdcc295cb947	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-001r-9380111000-1d3e64d9b459ae39a467	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-000i-0000009000-5100dfbf60152c10396a	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0fa9-2462579000-8be1675df78eeedb830e	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004l-9453300000-47690ecd3212cfb0e6e9	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-000i-0000009000-5b5256b2c5d57b0e59a5	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-000i-0100009000-c19e211ffbf84aed105c	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-8912000000-f0a81d7770210259a856	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-03di-0000011900-1affd5d6883c2a74a7af	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-03i0-0000092900-c3b864fa8a89e152c2dc	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-004i-0000191100-e85e1b942768955b124c	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0002-0000019000-1411195cac9f7c2b8802	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-03dk-0000079000-bdf6ee73bb0dec99c241	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-03di-0000192000-091ea4d0ae60edc91d1c	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0019-0600009000-17810cc02f639ee323f9	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0019-0600009000-17810cc02f639ee323f9	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-001i-0900003000-b093c23f9048f148685e	Spectrum

Biological Properties

Cellular Locations

Not Available

Biofluid Locations and Tissue Locations

Plasma
Ruminal Fluid
Serum

Concentrations

Biofluid	Status	Value	Condition	Species	Reference	Details
Plasma	Detected but not Quantified	Not Applicable	Not Available	Bovine	24630653	details
Plasma	Detected but not Quantified	Not Applicable	Not Available	Ovine	22242129	details
Plasma	Detected but not Quantified	Not Applicable	Not Available	Bovine	20647382	details
Ruminal Fluid	Detected and Quantified	0.002 uM	Not Available	Bovine	22959937	details
Ruminal Fluid	Detected and Quantified	0.002 uM	Not Available	Bovine	22959937	details
Ruminal Fluid	Detected and Quantified	0.002 uM	Not Available	Bovine	22959937	details
Ruminal Fluid	Detected and Quantified	0.003 uM	Not Available	Bovine	22959937	details
Serum	Detected and Quantified	3.4556 +/- 0.8645 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	3.7943 +/- 2.0639 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	3.4144 +/- 1.2528 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	3.3671 +/- 1.1598 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	3.6242 +/- 1.0444 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	2.94 +/- 0.98 uM	Not Available	Ovine	Candidate serum m...	details
Serum	Detected and Quantified	3.7052 +/- 0.9501 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	3.0753 +/- 0.7996 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	3.5445 +/- 0.683 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	3.1658 +/- 1.3213 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	3.4358 +/- 1.0029 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	3.2684 +/- 0.8953 uM	Normal	Ovine	Goldansaz et al.,...	details
Serum	Detected and Quantified	3.245 +/- 0.9762 uM	Normal	Ovine	Goldansaz et al.,...	details

External Links

DrugBank ID

Not Available

HMDB ID

HMDB0013462

FooDB ID

FDB029462

Phenol Explorer ID

Not Available

KNApSAcK ID

Not Available

BiGG ID

Not Available

BioCyc ID

Not Available

METLIN ID

Not Available

PDB ID

Not Available

Wikipedia Link

Sphingomyelin

Chemspider ID

Not Available

ChEBI ID

90011

PubChem Compound ID

53481777

Kegg Compound ID

C00550

YMDB ID

Not Available

ECMDB ID

Not Available

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Not Available

General References

Not Available

Showing metabocard for SM(d18:0/14:1(9Z)(OH)) (LMDB00624)

Structure for LMDB00624 (SM(d18:0/14:1(9Z)(OH)))